Scientists used RFID chips to track biological samples, according to a study published on May 31, 2018.
The main purpose of this study is to integrate organoids with digital technologies for advancements in the field of drug testing and transplantation. Study based on human organoids are found to be useful in the research related to human development and disease, as the structure, function and phenotype of our organs are replicated by them in the lab.
The integration of microchips will help in sensing, recording, and tracking changes of large quantities of organoids at the same time. Moreover, as the cells self-assemble into 3D structures during the growth process of an organoid, researchers thought that the microchip will naturally embed into the organoids as it grows. The chips were not introduced through injection, as it is highly toxic to organoids. Therefore, organoid’s natural self-cavitation power was used to integrate the microchips to prevent tissue damage and destruction.
Hybrid liver organoids integrated with cheap, commercially available radio frequency identification (RFID) chips were grown to test the procedure. It was observed that around 95% of their 96 test organoids successfully incorporated the chip. The organoids remained undamaged and they were shaped normally, secreted normal liver proteins, and transported bile as expected. Researchers say that there are still many limitations to this approach and further research is required to increase the production of these hybrid organoids.
Takanori Takebe, senior author of the study said, “My lab’s focus is completely biological, so some of these challenges are things we cannot resolve alone. But with collaboration between experts in different fields, and especially given how rapidly technology is evolving, I believe that we can and will solve them.”