Researchers from Mayo Clinic revealed gut bacteria may be reason behind failure to lose weight in certain people despite adhering to regular exercise and restricted calorie consumption
Obesity is the major health concern worldwide due to its adverse effects leading to severe complications. Several factors are involved in obesity range from genetics to environmental factors. Recent study revealed that genetic makeup of gut microbiome plays a major role in metabolism and weight loss. The study was published in Mayo Clinic Proceedings in July 2018.
Two genus of bacteria named Phascolarctobacterium and Dialister, were common type of bacteria associated with successful weight loss. Although, actual mechanisms these bacteria use to influence energy expenditure and metabolism is unknown at this stage, they could be initially used as biomarkers to tailor individualized weight loss programs. Furthermore, study measured the volume of genes that are known to encode gut microbial carbohydrate-active enzymes. It was found that those less able to lose weight displayed an increased capacity for carbohydrate metabolism.
This essentially means some people can more effectively metabolize carbohydrates, and subsequently have more difficulty in losing weight though caloric restriction and increased physical activity. The research is in preliminary stages, and further work needs to be done before a greater understanding into what specific gut bacteria could be releasing these carbohydrate-active enzymes, and whether interventions could be made to disrupt this mechanism. However, the study offers insight on role gut bacteria in modulating individual’s ability to metabolize certain carbohydrates.